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KMID : 0380020090240060549
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Korean Journal of Biotechnology and Bioengineering
2009 Volume.24 No. 6 p.549 ~ p.555
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Exmination of Anti-Obesity Effect of Regional Special Natural Products of Anthrisci radix, Psoraleae semen, Siegesbeckiae herba and Corni fructus
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Shin Jin-Hyuk
Cha Gu-Yong
Kim Hui-Jin
Hwang Jae-Ho
Han Kyeong-Ho
Seo Hyo-Jin
Shin Tai-Sun
Oh Suk-Jung
Kim Jong-Deog
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Abstract
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4 kinds of Regional Special Natural Products (RSNPs), such as Anthrisci radix, Psoraleae semen, Siegesbeckiae herba and Corni fructus were examined to verify for anti-obesity effect. PPARγ (peroxisome proliferator-activated receptor γ) from 3T3-L1 cell concerning adipocyte differentiation was suppressed by different concentraton of 4 RSNPs with western blot, when treated RSNPs’ extract and MDI (IBMX, Dexamethasone, Insulin) at the same time. Also, SREBP-1 (Sterol regulatory element binding protein) controlling lipogenesis and PPARγ expression levels were reduced by these 4 RSNPs’ extract, when these chemicals after differentiation of 3T3-L1 cell. And lipid droplets were reduced by 7.5%, 14.4%, 18.3% and 30% at different concentration of Anthrisci radix from Oil Red O staining. Also, it was reduced by 2%, 4.9%, 9.3% and 38% at different concentration of Psoraleae semen. For Siegesbeckiae herba, it was inhibited by 1.4%, 6.4%, 16.4% and 30.1%, respectively. And Corni fructus was also showed by 0.9%, 6.3%, 13.7% and 33% at same concentration of Siegesbeckiae herba. These 4 kinds of RSNPs were expected for a useful material for anti-obesity materials.
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KEYWORD
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anti-obesity, Anthrisci radix, Psoraleae semen, Siegesbeckiae herba, Corni fructus
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